结节性甲状腺肿与甲状腺癌P^(21WAF1)蛋白和层粘连蛋白的表达

Expressions of P^(21WAF1) Protein and Laminin in Thyroid of Nodular Goiter and Thyroid Cancer

目的研究P21WAF1蛋白和层粘连蛋白(LN)在结节性甲状腺肿中的表达水平及意义。方法应用免疫组化SP法检测50例结节性甲状腺肿、40例正常甲状腺组织、40例甲状腺癌标本中P21WAF1蛋白和LN的表达。结果P21WAF1蛋白和LN表达阳性率在结节性甲状腺肿分别为(52.14±29.02)%,(26.45±15.89)%;正常甲状腺组织为(87.01±7.21)%,(20.45±10.2)%;甲状腺癌为(14.20±12.04)%,(60.12±23.77)%;三者比较差异有显著性(P<0.01)。甲状腺癌P21WAF1和LN的表达呈负相关(r=-0.610,P<0.05)。结论P21WAF1和LN联合测定对鉴别良恶性甲状腺肿瘤有一定的临床价值。

Objective To explore expressions of P 21WAF1 protein and Laminin(LN) in nodular goite and its significance.Methods Immunohisto-chemistry method-SP was used to detect expressions of P 21WAF1 protein and LN in nodular goiter(50 cases),normal thyroid tissues(40 cases) and thyroid cancer(40 cases). Results The positive expressive rates of P 21WAF1 protein and LN were (52.14±29.02)% and (26.45±15.89)% in nodular goiter; (87.01±7.21)% and (20.45±10.2)% in normal thyroid tissues; and (14.20±12.04)% and (60.12±23.77)% in thyroid cancer (P<0.01), respectively. P 21WAF1 protein and LN expression positively related to the thyroid cancer.Conclusion The expression of alliance could got the beter value than the single expression for the patients with nodular goiter.