Ⅱ型糖尿病患者红细胞和血小板聚集变化及络泰对其的影响

Changes of Aggregation of Erythrocytes and Platelets in Non-insulin Dependent Diabetes Mellitus with the Effect of Luotai

目的探讨红细胞聚集、血小板聚集变化在Ⅱ型糖尿病(NIDDM)患者中的变化及络泰对其的影响。方法选用旋转锥板法及二磷酸腺苷(ADP)诱导比浊法对86例NIDDM患者红细胞聚集指数及血小板聚集率进行检测,并与30例健康人进行对比分析,同时选择30例患者进行络泰治疗前后对比。结果NIDDM患者红细胞聚集指数、血小板聚集率显著高于健康人(P<0.05),NIDDM患者合并血管病变较无并发症者这种变化更显著(P<0.05),络泰治疗后较治疗前红细胞聚集指数、血小板聚集率显著降低(P<0.05)。结论红细胞及血小板聚集变化在NIDDM血管并发症的发生发展过程中有重要意义,络泰具有抑制红细胞及血小板聚集、阻止并发症进程作用。

Objective To investigate changes of red blood cells aggregation and platelets aggregation in non-insulin dependent diabates mellitus(NIDDM) with the effect of luotai.Methods The levels of red blood cells aggregation and platelets aggregation determined in 86 cases patients with NIDDM to be detected by revolves and ADP specific turbid analysis and 30 normal people as controls. Anothor 30 patients were treated by luotai.Then the changes of red blood cells aggregation and platelets aggregation were determined.Results Compared with normal controls,the levels of red blood cells aggregation and platelets aggregation were higher (P<0.05).The alterations were notable especially in the patients complicated with vascular disease (P<0.05).The levels was lower treated by luotai than that not be treated (P<0.05). Conclusion The results suggest that red cells aggregation and platelets aggregation may play a important role in the pathogenesis of NIDDM.Luotai would inhibite the aggregation of red cells and platelets.