超敏C-反应蛋白、MMP-3与TIMP-1在急性冠脉综合征的表达

Expression of high sensitive C-reactive protein,matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 in patients with acute coronary syndrome

目的探讨急性冠脉综合征(ACS)患者血清超敏C-反应蛋白(hs-CRP)质金属蛋白酶3、基(MMP-3)、金属蛋白酶组织抑制剂1(TIMP-1)与冠状动脉粥样硬化斑块稳定性的关系。方法对58例ACS患者,12例稳定型心绞痛患者及15例正常体检者外周血血清hs-CRP、MMP-3、TIMP-1水平进行检测并进行相关性分析。结果ACS组血清hs-CRP、MMP-3水平与正常对照组的差异具有显著性(P<0.05,P<0.01),急性心肌梗死组患者TIMP-1水平与稳定型心绞痛组、不稳定型心绞痛组、正常对照组的比较有非常显著性差异(P<0.01)。ACS组间指标相关分析显示,血清hs-CRP水平与MMP-3水平无相关性(r=0.099,P=0.539),与TIMP-1水平有显著相关性(r=0.415,P=0.007),血清MMP-3水平与TIMP-1水平有显著相关性(r=0.333,P=0.033)。结论ACS患者血清hs-CRP、MMP-3、TIMP-1水平升高与ACS的发生关联,提示与动脉粥样硬化(AS)斑块不稳定有关。

Objective To investigate relationship of the serum high sensitive C-reactive protein (hs-CRP), matrix metalloproteinase-3 (MMP-3), and tissue inhibitor of metalloproteinase-1(TIMP-1), with coronary plaque stability.Methods The serum levels of hs-CRP,MMP-3 and TIMP-1 of 58 acute coronary syndrome(ACS) patients who included 20 patients of unstable angina (UA), and 38 patients with acute myocardial infarction(AMI), of 12 stable angina patients and 20 normal controls were detected,then their correlation were analysed.Results The serum levels of hs-CRP and MMP-3 in ACS group were higher than that in control group (P<0.05,P<0.01). The serum levels of TIMP-1 in AMI patients group was higher than that in SA group,UA group and control group(P<0.01).The correlation analysis in ACS group showed that there was no correlation between hs-CRP and MMP-3(r=0.099,P=0.539). There was a significant correlation between hs-CRP and TIMP-1(r=0.415,P=0.007). There was a significant correlation between MMP-3 and TIMP-1(r=0.333,P=0.033).Conclusions The serum levels of hs-CRP, MMP-3 and TIMP-1 are elevated in ACS patients,suggesting possible relation of hs-CRP, MMP-3 and TIMP-1 to the pathogenesis of ACS,thus the 3 indexes could been serviced as potential markers of plaque stability.