冠状动脉粥样硬化性心脏病中胰岛素的抵抗性

Insulin Resistance in Coronary Heart Disease

为探索冠心病中有无胰岛素抵抗性／高胰岛素血症及其在冠状动脉粥样硬化发生发展过程中的作用，本文检测了３２例非肥胖、口服葡萄糖耐量试验正常的单纯冠心病患者在服糖前后的血浆胰岛素、甘油三脂、总胆固醇浓度。结果表明，冠心病组病人存在餐后高胰岛素血症，血脂升高，这提示高胰岛素血症／胰岛素抵抗性可能是非糖尿病者发生冠心病的一个危险因素。

Resistance to insulin-stimulated glucose uptake is present in the majority of patients with impaired glucose tolerance or non-insulin dependents diabetes millitus (NIDDM)and in obese. Coronary heart disease(CHD) is prevalent in both obesies and diabetic condition with insulin resistance.To test whether CHD is associated with insulin resistance independently of obesisty and diabetes,we measured serum insulin levels during oralglucose tolerance test(OGTT) in 32 patients with CHD,who have normal body weight, normal blood pressure, and normal OGTT,and 23 normal subjects. Plasma triglyceride(TG)and total cholesterol(TC) were determined in fasting condition and after glucose load.We found that the insulin levels of CHD is much higher than those of controls after glucose load, meanwheal TG and TC levels are higher than those of controls. The results showed that CHD exists insulin resistance state or hyperinsulinemia; It may involve in the etiology and clinicalcourse of CHD as a risk factor.