医院获得性感染细菌耐药性影响因素分析

Analysis on factors affecting bacteria resistance in hospital aquired infections

目的研究在住院患者中分离的细菌耐药性影响因素。方法回顾性调查800份病历,分析住院时间、有无危险因素、病情是否严重等不同情况时细菌耐药性的差异。结果住院<15d的患者分离的肺炎克雷伯菌、流感嗜血杆菌和肺炎链球菌多于住院>15d的患者;而铜绿假单胞菌、不动杆菌属细菌少于住院>15d的患者。头孢曲松对住院3-15d、无危险因素、非重症患者分离的细菌保持了良好的抗菌活性,对肺炎链球菌和流感嗜血杆菌的敏感性达90％-100％,对大肠埃希菌和肺炎克雷伯菌的敏感性达70％-90％。结论非抗假单胞菌抗菌药物可用于住院<15d、无危险因素、非重症患者的抗感染经验治疗。

Objective To study the influence factor of bacteria resistance. Methods To investigate 800 cases of history and analyse the influence factor of bacteria resistance by different hospitalization; With or without endanger and whether serious. Results MoreKlebsiella pneumoniae , Haemophilus infruenzae ,Streptococcus pneumoniae and less Pseudomonas aeruginosa、Acinetobacte , spp were isolated from these in patients wthin 15 days than over 15 days. The ceftriaxone showed excellent activity against Strepocouus pneumoniae , Haemophilus influ-enzae ,E. Coli and K/ebsieHa pneumoniae , which were isolated from the in patients between 3 - 15days,not endanger, not serious. The sensibility of ceftriaxone to Streptococcus pneumoniae,Haemophilus influenzae , were 90% - 100%;ToE. coli and K. pneumoniae were 70% - 90%. Conclusions No anti -pseudomonas antibiotics may be used for those in patients less than 15 days not endanger, not seriously illed patients.