氟斑牙患者服硒后体内氟和抗氧化酶类的变化

Changes or fluoride level and antioxidative enzyme activity in dental fluorosis patients after sodium selenite administration

测试了氟斑牙患者服亚硒酸钠前后血、尿、发Ｓｅ和血、尿Ｆ－，血液谷胱甘肽过氧化物酶（ＧＳＨ—Ｐｘ），超氧化物歧化酶（ＳＯＤ）和血清脂质过氧化物（ＬＰＯ）。结果血、尿、发Ｓｅ含量升高，血Ｆ－降低，尿Ｆ－排泄增加，血液ＧＳＨ—Ｐｘ、ＳＯＤ活性增强，ＬＰＯ含量下降，血ＧＳＨ—Ｐｘ／ＬＰＯ和ＳＯＤ／ＬＰＯ比值升高．表明硒可拮抗体内高氟，血液抗氧化酶类活性增强。本文就其相互关系以及在氟中毒发病中的作用进行了讨论。

We examined the levels of Selenium(Se)in serum,urine and hair,and fluoride(F-) in serum and urine,the activity of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) in RBC,as well as the level of lipid peroxide (LPO) in serum from dental fluorosis patients before and after sodium selenite(Na2SeO3) administration. The results demonstrated that the levels of Se in serum,urine and hair were increased; that of F- in serum was decreased and the excretion level of F-in urine was increased. The results also snowed that both the activity of GSH-Px and DOS were increased in RBC and the level of LPO was decreased in serum; the ratios of GSH-Px/LPO,SOD/LPO appeared higher in patients after Na2SeO3 administration. The results suggested that Se may be an anti-fluoride agent by strengthening the activity of such anti-oxidative enzymes in human bodies. We also disussed the effects and mutual relationships among these parameters on the occurrence of fluorosis.