脱碘酶活性改变在克山病发病机制中的作用

Effect on pathogenesis of Keshan Disease by change of thyroxine 5'-monodenase activity

本文测定了饲克山病病区粮大鼠心、肝、肾、甲状腺Ｔ．５＇－脱单碘酶活性。结果表明病区粮组大鼠心、肝、肾组织中的脱碘酶活性明显降低，并在补硒、维生素Ｅ后可使脱碘酶活力恢复正常。提示脱碘酶活性的改变在克山病发病中可能起着重要的作用。

In this paper,writers investigate the activities of myocardial hepatic and renal thyroxine 5' monodiodinose of rats fed with grains from a KD endemic area. The results showed that myocardral,hepatic and renal thyroxine 5'-monodeiodinose activities were significantly reduced in rats fed with grains from a endemic area. This enzyme activity was effectively enhanced through Se or/and VE supplementation to the diet. It suggested that changes of Thyroxine 5'-monodeiodinase activity may play an important role in Keshan Disease attack.