摘要
用高碘水喂养昆明种雄性小鼠,观察到高碘水引起小鼠甲状腺相对重量增加28.9%(P<0.05),甲状腺滤泡充盈扩张及上皮细胞扁平;血清T4增高31.8%(P<0.01),rT3增高29.3%(P<0.05),T3降低27.3%(P<0.05);肝5′-脱碘酶活性下降26.5%(P<0.05)。提示高碘甲状腺肿动物血清T4增高原因是高碘抑制了分解T4的5′-脱碘酶,使T4向T3转化减少。
The Kun Ming male mice were fed with high iodine water.Three months later,the mice showed(1) the relative weight of thyroid increased by 28.9%(P<0.05),the thyroid folliculi were plentiful and dilating,and the epithelia were flat; (2) the level of serum T4 increased by 31.8%(P<0.01)and rT3 by 29.3%(P<0.05),and that of T3 decreased by 27.3%(P<0.05)and (3) the activity of 5′-Deiodinase lowered by 26.5%(P<0.05).It was considered that the increase in blood T4 could be attributable to inhibition of excess iodine from 5′-D resolving T4,resulting in decrease of conversion of T4 to T3.
出处
《中国地方病学杂志》
CAS
CSCD
1994年第4期206-208,共3页
Chinese Jouranl of Endemiology