克山病致病因素对大鼠心肌线粒体α－磷酸甘油脱氢酶的影响

Effect of the pathogenic factors of Keshan Disease on activity of myocardial mitochondria α-Glycerophosphate Dehydrogenase in rats

测定了克山病病区粮喂养大鼠心肌线粒体α－磷酸甘油脱氢酶（ａ－ＧＰＤ）活性，并观察了硒和维生素Ｅ对该酶的影响。结果表明，病区粮组大鼠心肌线粒体α－ＧＰＤ活力明显低于非病区粮组和常规．食组，并在补０．１μｇ／ｇ＋８００μｇ／ｇＶＥ后，α－ＧＰＤ活性升高与病区粮组比较有显著差异、本实验结果提示：１、饲克山病病区粮大鼠心肌线粒体α－ＧＰＤ活力的降低，此时的心肌可能处于甲状腺激素功能低下状态．２、硒（０．１μｇ／ｇ）＋维生素Ｅ（８００μｇ／ｇ）的补充可以升高该酶活性，改善甲状腺激素功能不足状态。

In this paper, writters investigated the myocardial mitochondria α-glycerophosphate dehydrogenase(α-GPD)activity of rats fed grains from a Keshan disease (KD) endemic areas and effects of Se and VE on α-GPD. The results showed that myocardia mitochondria α-GPD activity was significantly reduced in endemic group than that in non-endemic group and stock group. The activity of α-GPD was significantly increased through Se (0.1μg/g) +VE(800μg/g) supplementation to the diet. The results suggested that:1 myocardial mitochondria α-GPD activity of rats red grains from a KD areas was decreased, indicating that myocardium of endemic group was in a thyroidhormone-deficient status. 2 Se and VE can improve thyroid hormone deficient status.