摘要
目的:探讨缬沙坦对肾性高血压大鼠血管内皮细胞的保护作用。方法:包埋左肾制备高血压大鼠模型,给予缬沙坦治疗5周,尾容积法测动物血压,观察缬沙坦组与高血压组血压变化并应用多导电生理记录仪描记心电图,放免法测定各组血浆血管紧张素(angiotensin,AngⅡ)和内皮素(endothelin,ET-1)水平,硝酸还原酶法测定一氧化氮(nitric-oxide,NO)水平。结果:缬沙坦可使肾性高血压大鼠血压回降84%,血浆AngⅡ含量升高26.2%,NO含量升高64.4%,ET-1含量下降49.1%(P< 0.01)。缬沙坦组与高血压组心率变异各指标无明显差异(P>0.05)。结论:缬沙坦通过促进内皮细胞分泌NO,抑制内皮细胞分泌内皮素,对肾性高血压大鼠血管内皮细胞功能具有保护作用。
Objective: To explore the protective effect of valsartan on the vessel endotheliocytes in rats with renal hypertension. Method: The rats'model with renal hypertension was made, the rats were treated with valsartan for 5 weeks. The blood pressure and ECG were recorded. The plasma levels of NO,AngⅡ, and ET were measured in each group. Result: The levels of plasma AngⅡ and ET with hypertension were significantly higher(P<0.01) those of controlled group, but the levels of plasma NO was lower than those of controlled group(P<0.01) . In rats with hypertension, the SBP were significantly declined(P<0.01) , the levels of plasma Ang Ⅱ and NO were increased(P<0.01) after the treatment with valsartan,and the levels of plasma ET was decreased. Conclusion: The treatment with valsartan plays an important role in protecting the endothelial function through inhibiting endotheliocytes to excret ET and promot endotheliocytes to excret NO.
出处
《中国药师》
CAS
2005年第5期402-403,共2页
China Pharmacist
