摘要
目的:探讨前S1抗原在血清学模式HBsAg+、HBeAg+ /Anti-HBe+和Anti-HBC+患者中的临床意义。方法:检测199例HBsAg+、HBeAg+和Anti-HBC+(“模式1”), 185例HBsAg+、Anti-HBe+和Anti-HBC+(“模式2”)患者标本的HBV-DNA前S1抗原和肝功能相关指标ALT、GGT。结果: 199例“模式1”标本中HBV-DNA阳性189例(阳性率95 .0% ),前S1抗原阳性86例(阳性率43. 2% )、肝功能异常33例(异常率38 .37% ),前S1抗原与HBV-DNA阳性率不相关(P>0 .05), 前S1抗原阳性率与肝功能异常率不关联(P>0. 05 ); 185例“模式2”标本中HBV-DNA阳性94例(阳性率50 .81% ),前S1抗原阳性54例(阳性率29. 2% )、肝功能异常35例(异常率68 .81% ),前S1抗原阳性率与HBV-DNA阳性率相关(P<0 .05), 前S1抗原阳性率与肝功能异常率有关联(P<0 05)。结论:前S1抗原在“模式2”患者中能反映乙肝病毒复制,可作为肝功能损害的参考指标;但在“模式1”患者中不能反映乙肝病毒复制和作为肝功能损害的参考指标。
Objective:To discuss the clinical significance of the PreS1 antigen in the HBV infected patients of different serologic models.Methods:HBV-DNA, PreS1 antigen, ALT and GGT were determined in 199 patients of HBsAg+, HBeAg+ and Anti-HBC+(Model 1) and 185 patients of HBsAg+, Anti-HBe+ and Anti-HBC+(Model 2).Results:189 HBV-DNA and 86 PreS1 antigen and 33 hepa-dysfunction were found in the 199 patients of Model 1 and 94 HBV-DNA, 54 PreS1 antigen and 35 hepa-dysfunction were found in the 185 patients of Model 2.PreS1 antigen was not correlated with HBV-DNA and hepa-dysfunction in the patients of Model 1, and PreS1 antigen was correlated with HBV-DNA and hepa-dysfunction in the patients of Model 2.Conclusion:PreS1 antigen could be taken as the copy indicator of HBV and as a referencing indicator of the injury of the liver in the patients of Model 2, and could not be taken as that in the patients of Model 1.
出处
《中国卫生检验杂志》
CAS
2005年第5期544-545,共2页
Chinese Journal of Health Laboratory Technology