盐酸丁咯地尔治疗脑动脉硬化记忆障碍研究

Study of buflomedil in the treatment of dysmnesia of cerebral arteriosclerosis

目的研究盐酸丁咯地尔治疗对脑动脉硬化记忆障碍患者记忆功能、脑血流量、脑电图等的影响。方法脑动脉硬化记忆障碍患者76例,随机分为研究组(42例)和对照组(34例),分别给予盐酸丁咯地尔0.1g与胞二磷胆碱0.5g静脉滴注,每日1次共8周。治疗前后记忆测定及经颅多谱勒、脑电图检查。结果研究组即刻记忆和临床全面记忆能力较对照组明显改善(P<0.01);盐酸丁咯地尔治疗后患者脑血流指标、脑电图改善亦较对照组显著(P<0.05～0.01)。结论盐酸丁咯地尔治疗可提高脑动脉硬化记忆障碍患者的脑血流量,改善脑电图从而改善患者的记忆能力。

Objective:To study the effect of buflomedil on memorial functi on ,cerebral blood flowand electroencephalogram(EEG)of the patients with dysmnes ia of cerebral arteriosclerosis.Methods:76patients with dysmnesia of cerebral ar teriosclerosis were randomly divided into study group(42cases)and control grou p(34cases).They were given buflomedil0.1g or diphosphocholine0.5g by intraveno us drip once a day for8weeks respectively.The memorial test,transcranial dopple r and EEG in both groups were measured respectively before and after treatˉment .Results:The immediate memory and overall memory were significantly improved in b uflomedil group compared with the control group(P<0.01),meanwhile the cerebra l blood flow and EEG were also improved in buflomedil group comarped with contro l group after treatment(P<0.05～0.01).Conclusion:The results showed that buflo medil could improve cerebral blood flowand decrease the degree of EEG abnormalit y,thus,it had a good benifits for the patients with dysmnesia of cerebral arte riosclerosis.