心脏和肾脏短暂缺血对心肌梗死后心律失常的影响

The influence of myocardial and renal infarction preconditioning on arrhythmias in acute myocardial infarction

目的 研究心脏和肾脏短暂缺血预处理对急性心肌梗死(AMI)后心律失常的影响。方法 观察AMI组(A组)、心脏缺血预处理(MIP)组(B组)和肾脏缺血预处理(RIP)组(C组)新西兰兔在AMI前后的心律失常情况及QT间期离散度(QTd) ,并行心内电生理诱发室性心动过速(VT) ,对三组的指标进行比较,同时设置假手术组(D组)作对照。结果 四组在手术前心律失常及QTd差异无显著意义(P >0 . 0 5 ) ;D组手术前后心律失常及QTd比较差异无显著意义(P >0 . 0 5 ) ;在AMI后,B、C两组室性心律失常及QTd明显小于A组(P <0 . 0 5 ) ,而B、C两组室性心律失常及QTd比较差异无显著意义(P >0 .0 5 )。结论 MIP和RIP均可减少AMI后室性心律失常的发生,而且两者的作用没有明显差异。

Objective To study the influence of myocardial infarction preconditioning(MIP) and Renal infarction preconditioning(RIP) on arrhythmias after acute myocardial infarction(AMI).Methods Arrhythmias and QT dispersion(QTd) of group A(rabbits without IP),group B(rabbits with MIP) and group C(rabbits with RIP) were measured after AMI,and electrophysiologic examination was made to induce ventricular tachycardia(VT).The gained indexes of three groups were analyzed and compared with each other.Group D(sham operation) was served as control.Results Arrhythmias and QTd of each group had no significant changes before operation(P>0.05).Arrhythmias and QTd of group D had no significant changes before and after operation(P>0.05).After AMI,the rate of ventricular arrhythmias and QTd of group B and group C after AMI were significantly lower than that of group A(P<0.05).Group B was well-matched with that of group A(P>0.05).Conclusion The rate of ventricular arrhythmias and QTd in group B(with MIP) and group C(rabbits with RIP) were significantly lower than that of group A(without IP),and the treatments of MIP and RIP had no significant changes.