摘要
目的 观察补肾益肝活血胶囊对去卵巢大鼠骨质疏松症的影响。方法 6月龄大鼠随机分为假手术组(N)、模型组(O)、模型+尼尔雌醇处理组(O +E)、模型+补肾益肝活血胶囊处理组(O +M )。治疗90d后,测定尿脱氧吡啶啉/肌酐比率(urinarydeoxypyridinotinecrosstink/crertinine,udpd/Cr) ,血Ca、palp、尿Ca/Cr等生化指标,观测股骨近端骨密度、组织形态学变化情况。结果 模型+补肾益肝活血胶囊处理组(O+M)骨密度增加,尿脱氧吡啶啉/肌酐比率显著下降,血钙、血磷显著增高,碱性磷酸酶下降。结论 补肾益肝活血胶囊不仅能抑制骨吸收,还能促进骨形成,具有较好的防治骨质疏松作用。
Objective To observe the effect of Bushenyiganhuoxue capsule on osteoporosis of off-ovary rats.Methods Six-month rats were divided randomly into four groups:pseudo-operation group(N),model group(O),model-and-nylestriol group(O+E) and model-and-Bushenyiganhuoxue capsule group(O+M).90 days later,urinary dexoxypyridinotine scorrtink/crertin-ine(udpd/Cr)ratio,plasma Ca palp and urinary Ca/Cr were detected.Meanwhile we observed osteodensity of thighbone and tectolgy changing.Results In group (O+M),osteodensity increased and udpd/Cr de-creased markedly,with increased plasma Ca plasma P,and decreased alkaline phosphatase.Conclusion Bushenyiganhuoxue capsule can not only restrain osteo-absorption,but also accelerate osteogenesis,it a preferable action of preventing osteoporosis.
出处
《中国基层医药》
CAS
2005年第4期416-417,共2页
Chinese Journal of Primary Medicine and Pharmacy
基金
珠海市科技项目 (PC2 0 0 410 2 3 )
