鼻塞式持续呼吸道正压给氧对新生儿呼吸衰竭血气及疗效的影响

The effects of nose-stuffy CPAP on the blood gas analysis and effect of treatment in neonatal respiration failure

目的 探讨鼻塞式持续呼吸道正压给氧(CPAP)对新生儿呼吸衰竭血气及疗效的影响,以观察CPAP的临床应用价值。方法 对32例呼吸衰竭新生儿采用鼻塞式CPAP给氧治疗,观察治疗后1h血气改善情况及临床疗效,并与2 8例头罩给氧的对照组进行比较。结果 治疗组CPAP后PaO2 和SaO2 较CPAP前明显升高(P <0 . 0 1) ,pH和PaCO2 无明显变化(P >0 .0 5 )。氧疗前后PaO2 和SaO2 升高值治疗组较大,两组比较差异有显著意义(P均<0 .0 5 ) ,pH升高值和PaCO2 下降值两组差异无显著意义(P均>0 . 0 5 )。治疗组总有效率、存活率分别为84 %、88% ,明显高于对照组的5 4 %、6 8% (P <0 . 0 1,P <0 .0 5 )。结论 鼻塞式CPAP是治疗新生儿呼吸衰竭的有效方法,能纠正严重低氧血症,改善血气,提高疗效及存活率。

Objective To study the effects of nose-stuffy continuous positive airway pressure(CPAP) on the blood gas analysis and effect of treatment in neonatal respiration failure,and evaluate the clinical value of CPAP.Methods 32 neonates with respiratory failure were treated with nose-stuffy CPAP oxygen,to observe the changes of blood gas,clinical effects after 1 hour,and 28 cases with face-guard oxygen treatment were compared.Results PaO_2 and SaO_2 after CPAP in treatment grorp were higher than that before CPAP(P<0.01),there were no obvious changes in pH and PaCO_2(P>0.05).There wcre significant difference in PaO_2 and SaO_2 before and after oxygen treatment between the two grorps(P<0.05),the value of pH and PaCO_2 had no significant difference(P>0.05).The total validity rate and the survival rate in the treating group were 84% and 88%,they are higher than 54% and 68% in the control group(P<0.01,P<0.05).Conclusion The nose-stuffy CPAP is an effective method to treat neonatal respiration failure,which can change blood gas and correct serious low-blood-oxygen symptom,and improve the effect of treatment and the survival rate.