冠心病患者同型半胱氨酸水平变化与血管内皮功能的关系

Alteration of blood homocysteine in patients with coronary heart disease and its correlation with the vascular endothelial function

目的:探讨血浆同型半胱氨酸水平变化对冠心病患病的意义以及与内皮素、一氧化氮的相关性。方法:分别测定115例冠心病患者和52例正常对照组血浆同型半胱氨酸及血脂各参数、内皮素、一氧化氮水平,并进行比较。结果:冠心病组的同型半胱氨酸、内皮素水平均明显高于对照组(P<0.01),而一氧化氮低于对照组(P<0.01)。结论:半胱氨酸与冠心病具有密切联系,高同型半胱氨酸是同型半胱氨酸患者的一个新的危险因素,检测血浆同型半胱氨酸对预防和诊治冠心病具有一定临床价值。

Objective To investigate the implication of hyperhomocysteinemia in coronary heart disease and the correlation between homocysteine and the vascular endothelial function. Methods The fasting plasma total homocysteine, serum triglyceride, total cholesterol, high density lipoproteincholesterol, low density lipoprotein-cholesterol, nitrogen monoxide and endothelin of 115 case of affirmed coronary heart disease and 52 age and gender matched controls were determined respectively. Statistical analysis was done to all measured parameters. Results The homocysteine and ET levels were significantly higher in coronary heart disease group than those in control group. The nitrogen monoxide levels were significantly lower in coronary heart disease group than those in control group. Conclusion Plasma homocysteine level is closely related with coronary heart disease and hyperhomocysteinemia is a risk factor for coronary heart disease.