妥泰快速加量治疗小儿癫癎疗效及安全性研究

Study on the effect and security of topamax fast adding-ontreatment forchildren with epilepsy

目的:评价妥泰快速加量治疗儿童癫(?)疗效及安全性。方法:将92例癫(?)患几分成2组,一组为常规加量组,一组为快速加量组,两组初始剂量均为0.5-1mg/(kg·d),常规加量组每周加量0.5-1mg/(kg·d),4-8周迭治疗量,快速加量组为每3天加量0.5-1mg/(kg·d),10-20d达治疗量,分别观察其疗效及不良反应。结果:常规加量组与快速加量组的有效率分别为87.80%和86.36%(P>0.05),用药第4周末常规加量组有效率为43.47%,快速加量组为68.89%,有效率明显增加,(P<0.05)。常规加量组的不良反应发生率为28.26%,快速加量组为32.15%,持续时间,严重程度相近。结论:妥泰快速加量治疗癫(?),可提高患儿依从性,安全有效。

Objective To assess the topamax therapeutic effect and security of fast adding-on treatment on children with epilepsy. Methods Ninety-two patients were divided into two groups,one group was treated with the routine adding-on,and the other group was treated with the fast adding-on ,the initial dose of two groups were all 0. 5-1 mg/(kg·d). The adding amount of the routine group was 0. 5-1 mg/(kg·d) weekly. After 4-8 weeks, topamax' dosage would get to the treating amount. And for the fast adding-on group,the same amount was added once every three days. Ten to twenty days later, dosage would reach treating amount. The therapeutic effect and security were observed respectively. Results The effective rate of the routine adding-on group was 87. 80%,and the fast adding-on group was 86. 36%. Two groups had no obvious difference. But on the fourth weekend, the routine group's efficient was 43. 47%,and the fast adding-on group was 68. 87%. The effective rate was obviously improved. The later had higher effect. For the side effect, the incidence of the routine group was 28. 26%,and the fast adding-on group was 32. 16%. The duration and severity of their side effects were similar. Conclusions The fast adding-on topamax to treat children's epilepsy could raise the compliance of children with epilepsy. It will be a valuable method that is worth popularing and applying safely on clinic.