EGF和EGFR在肝细胞癌中的表达及临床意义

Expression and clinical significance of EGF and EGFR in human hepatocellular carcinoma

目的研究表皮生长因子(EG F)及其受体(EG FR)在肝细胞癌(H C C)组织中的表达及其与临床病理的关系。方法应用免疫组化S蛳P方法检测55例H C C患者癌组织及癌旁肝组织中EG F和EG FR的表达情况。结果在55例H C C患者癌组织及其癌旁组织中,EG F阳性表达率分别为54.55%(30/55)和76.36%(42/55),两者差异有显著性(P<0.05);EG FR阳性表达率分别为58.18%(32/55)和36.36%(20/55),两者差异有显著性(P<0.05)。EG FR在H C C组织中的阳性表达率与临床分期、门静脉癌栓、肝外转移、术后复发等显著相关,而与肿瘤直径、肿瘤数目、血清AFP水平以及分化程度无明显关系。EG F阳性表达率与各临床病理参数无关。结论EG F可能与H C C的发生、发展无关;而EG FR与H C C的发生、发展有关,可作为预测H C C复发、转移的参考指标。

Objective To investigate the expression and clinicopathological significance of the epidermal growth factor (EGF) and epidermal growth factor receptor (EGFR) in human HCC tissues. Methods Immunohistochemistry was employed to determine the expression of EGF and EGFR in 55 HCC tissues and their adjacent liver tissues. Results The positive rate of EGF was significantly lower in the HCC tissue (54.55 %,30/55) than in the adjacent liver tissue (76.36 %, 42/55) (P <0.05). The positive rate of EGFR in the HCC tissue (58.18 %, 32/55) was markedly higher than that in the adjacent liver tissue (36.36 %,20/55)(P <0.05). The expression of EGFR in the HCC tissue was significantly correlated with the clinical stage, the Portal vein tumor thrombus, the presence of extrahepatic metastasis, and the recurrence of tumor, but not correlated with the diameter of tumor, the number of tumor, the level of serum alpha- fetoprotein (AFP) and the differentiation of tumor. The expression rate of EGF was not correlated with the clinicopathological parameters. Conclusions EGF may not be involved in the initiation and progression of HCC, whereas, EGFR relates to the initiation and progression of HCC. EGFR can be considered as a marker for predicting the metastasis and recurrence of HCC.