HGF、C-Met在子宫内膜异位症患者在位子宫内膜的表达及意义

Expression and significance of hepatocyte growth factor and C-Met in the eutopic endometrium of endometriosis

目的:探讨肝细胞生长因子(H G F)及其受体(C-M et)与子宫内膜异位症发病机制的关系。方法:采用链霉素抗生物素蛋白-过氧化物酶(S-P)法检测45例(增生期20例,分泌期25例)盆腔子宫内膜异位症及30例(增生期12例,分泌期18例非子宫内膜异位症妇女的在位子宫内膜的H G F与C-M et的免疫表达水平。结果:(1)盆腔子)宫内膜异位症的在位子宫内膜的H G F、C-M et表达水平显著增高P=0.006,P=0.001)。(2)H G F与C-M et呈正相(关(异位症及对照组r均为0.945)。(3)H G F与C-M et均随月经发生周期性变化(分泌期高于增生期,对照组H G F、C-M et分别为P=0.015、P=0.023;内异症组H G F、C-M et分别为P=0.003、P=0.015)。结论:类似肿瘤转移和浸润机制,H G F/C-M et系统可能参与了子宫内膜异位症的发病。

Objective To investigate the expression of hepatocyte growth factor (HGF) and C Met in the eutopic endometrium of pelvic endometriosis and the relationship between HGF and C Met in the pathogenesis of endometriosis. Methods The expression of HGF and C Met in the eutopic endometrium of forty five women with pelvic endometriosis(proliferative phase:n=20, secretory phase:n=25)and thirty women without endometriosis(proliferative phase:n=12,secretory phase:n=18)were detected with streptavidin peroxidase(S P) immunohistochemical method. Results (1)The expression of HGF and C Met were markedly higher in the eutopic endometrium of patients with pelvic endometriosis than in that of controls (P=0.006, P=0.001, respectively).(2)There had a positive correlation between the expression of HGF and C Met both in endometriosis and in without endometriosis (r=0.945).(3)We also found a significant correlation of HGF and C Met with menstrual cycle(proliferative was higher than secretory. HGF &C Met of control:P=0.015, P=0.023, respectively. HGF &C Met of endometriosis:P=0.003, P=0.015). Conclusion Analogous to tumor metastasis and invasive mechanism, HGF and C Met may be involved in the pathogenesis of endometriosis.