摘要
目的: 探讨老年腹膜透析(腹透)患者血清瘦素水平与营养状况的关系。方法: 老年腹透组患者41例、非老年腹透组患者19例和正常对照组20例为研究对象,采用ELISA法测定血清瘦素水平,分析瘦素水平与肾功能、前白蛋白、白蛋白、补体、转铁蛋白、血脂、人体学测定和主观全面营养评估指数的相关性。结果: 老年腹透组和非老年腹透组患者血清瘦素水平均显著高于对照组,且老年腹透组患者血清瘦素水平较非老年腹透组显著增高;老年腹透组患者血清前白蛋白、白蛋白、转铁蛋白、补体和人体学测定等客观营养指标均低下,且与血清瘦素水平呈显著负相关;老年腹透组患者存在营养不良,且营养状况越差,血清瘦素水平越高。结论: 老年腹透组患者血清瘦素水平较非老年腹透组患者和健康人显著增高;老年腹透患者血清瘦素水平增高可能参与了其营养不良的发病。
Objective: To investigate the relationship between serum leptin level and nutritional condition of elderly patients undergoing maintenance peritoneal dialysis (PD). Methods: Forty-one elderly PD patients (EPD), nineteen young HD patients (YHD) and twenty healthy subjects for control were enrolled in this study. Serum leptin was detected by ELISA with simultaneous determination of the renal function, prealbumin, albumin (ALB), complement (C_ 3), transferrin (TF), lipids, Body measurement and subjective global assessment (SGA). Correlation analysis between serum leptin level and degree of malnutrition were performed. Results: Serum leptin level in EPD and YPD patients were significantly higher than that in healthy control group, and there was significantly higher in EPD than that in YPD. There was significantly correlation between serum leptin, albumin, transfurrin, C_ 3 and the body measurement. Assessment by SGA demonstrated presence of malnutrition in EPD patients, which was also significantly correlation between serum leptin and SGA in EPD patients. Conclusion:The results suggested that the presence of the elevated serum leptin level in EHD patients,Which may be responsible for malnutrition in EPD patients.
出处
《中国临床医学》
北大核心
2005年第2期282-284,共3页
Chinese Journal of Clinical Medicine
基金
上海市卫生局青年科研基金 (00Y48)
上海市医苑新星基金资助
