外周血P-选择素检测对判断类风湿关节炎活动期的意义

The Clinical Implication of P-selectin level in Rheumatoid Arthritis

目的:探讨外周血P 选择素表达对判断类风湿性关节炎(RA)活动期的意义。方法:用流式细胞术检测18 例活动期RA、10例缓解期RA患者与15例正常人外周血P 选择素的表达,同时免疫比浊法测定C反应蛋白(CRP)与魏氏法测定血沉(ESR)。结果:活动期RA组患者的外周血P 选择素表达(11.88%±2.47%)明显高于缓解期RA组(2.85%±1.60%),也明显高于正常对照组(2.78%±1.04%)(P<0.01);活动期RA组CRP(54.33±23.35 mg/L)与ESR(86.06±33.67 mm/1h)明显高于缓解期RA组(2.55±1.01mg/L与14.70±4.57mm/1 h),也明显高于正常对照组(3.21±2.18 mg/L与12.25±5.05mm/1h)(P均<0.01);活动期RA患者组P 选择素的表达量与ESR、CRP呈直线正相关,相关系数r分别为0.52(P<0.01)与0.70(P<0.01)。结论:P 选择素高度表达对判断RA活动可能有意义。

Objective: To explore the significance of P-selectin level in patients with rheumatoid arthritis (RA). Methods: The level of P-selectin was detected by flow cytometry in 18 active RA patients,10 remission RA and 15 normal controls.At the same time,the erythrocyte sedimentation rate (ESR) and C-reactive protein were determined in all groups. Results: The level of P-selectin in RA patients (11.88%±2.47%) was significantly higher than that in remission RA group (2.85%±1.60%) (P<0.01),and that in control group (2.78%±1.04%) (P<0.01). The level of CRP (54.33± 23.35 mg/L) and the ESR( 86.06± 33.67 mm/1h) in RA patients were higher than that in remission RA group (2.55±1.01 mg/L, 14.70±4.57 mm/1h) (P<0.01), and that in normal controls (3.21±2.18 mg/L,12.25±5.05 mm/1h) (P< 0.01).There was a correlation between P-selectin and ESR (r=0.52, P<0.01)and also a correlation between P-selectin and CRP (r=0.70, P<0.01). Conclusion:The active RA patients had highly-expressed P-selectin, which may be a sign of RA exacerbation.