高血压病左室舒张功能异常超声心动图各项指标相关性分析

The Correlation of Ventricular Diastolic Function with other Echocardiographic Parameters in Patients with Essential Hypertension

应用脉冲多普勒超声法测定39例较中度高血压病（EH）患者和正常人左室舒张功能各项参数，进行相关性分析，结果显示：EH组PVE变小，PVA增大，PVE／PVA比值缩小，IRT延长，LVmass和LVmI增加，LAD增大，均与对照组相差显著（P＜0．05～0001）。PVE／PVA，IRT和LVmass均与MAP呈相关性（r＝－0.37，0．37，0．41）；LVmass与PVE／PVA，IRT，LAD和LVmI相关性好（r＝－0．41，0．38，0．53，0．96）；且IRT与PVE／PVA呈负相关（r＝－0．43）。研究表明，EH患者早期常出现左室舒张功能异常，测量PVE／PVA及IRT便捷、直观。左室舒张功能受累还常伴有左房内径扩大和LVmI增加。

Pulsed Doppler echocardiogram analysis of left ventricular (LV) diastolic function was performed in 39 patients with mild to moderate essential hypertension (EH) and the healthy volunteers. The results showed that the peak velocity of early left ventricu1ar filling(PVE) was decreased and the peak velocity of late ventricular filling (PVA) was increased in the EH group. The ratio of PVE/PVA was decreased. The isovolumic relaxation time (IRT) was prolonged,LV mass was increased and the left atrial diameter(LAD) enlarged. These parameters were significantly different from the contro1 group (P<0.01 ~0.001). PVE/PVA and IRT were closely related to MAP and LVM,and IRT negatively related to PVE/PVA. It is suggested that the abnormality of LV diastolic function often exists in mild to moderate EH before hypertrophy.