期刊文献+

药物洗脱支架直接置入术治疗急性心肌梗死的临床观察

The application of cypher drug-eluting stent in patients with acute myocardial infarction receiving emergency percutaneous coronary intervention
下载PDF
导出
摘要 目的观察急性心肌梗死(AMI)时行无球囊预扩张直接置入雷帕霉素药物洗脱支架(CYPHERTM,codis)治疗的临床效果。方法对21例AMI患者在发病12h内,未经球囊预扩张而直接置入药物洗脱支架。梗死相关血管(IRA)共21支,左前降支10例,左回旋支4例,右冠状动脉7例。心肌梗死溶栓试验(TIMI)血流1级10例、2级9例、3级2例。结果21例患者共置入21个CYPHERTM支架,支架置入后TIMI血流3级20例、2级1例,残余狭窄为3±4.1%,支架置入成功率100%。住院期间无一例死亡,也无再次心肌梗死及再次靶病变需重复再通治疗。结论急性心肌梗死(AMI)时行无球囊预扩张直接置入雷帕霉素药物洗脱支架治疗,成功率高,并发症少,安全可行。 Objective To investigate the feasibility, safety and efficacy of cypher drug-eluting stent implanting in patients with acute myocardial infarction receiving emergency percutaneous coronary intervention(PCI). Methods From March, 2003 to March,2004, CYPHER stent was directly deployed without ballon predilation in 21 patients within 12 hours from onset. Single vessel disease was in 11 patients, double vessel disease in 5 patients and triple vessel disease in 5 patients. Infarct-related arteries (IRA) were left anterior descending artery in 10 patients, left circumflex in 4 patients ,right coronary artery in 7 patients . Thrombolysis in myocardial infarction TIMI 1 flow in 10 patients, TIMI2 flow in 9 patients ,TIMI 3 flow in 2 patients. Results Twenty-one stents were implanted. Post-stenting residual stenosis decreased to (3±4.1)%, stent deployment was successful in 100% of the cases, There were no complications, no death, no Q-wave or non-Q-wave myocardial infarction and no repeated revasculariation during the hospitalization. Conclusion Direct CYPHER stenting without predilatation can be performed in AMI with its high successful rate and low complication.
出处 《中国心血管病研究》 CAS 2005年第5期350-352,共3页 Chinese Journal of Cardiovascular Research
  • 相关文献

参考文献9

  • 1[1]Park SW, park SJ,Hong MK, et al. Intracoronary stenting in patients with acute myocardial infarction .JACC, 1997,29(Suppl A) :456A
  • 2[2]Ryan TJ, Faxon DP, Gunnar RM, et al. Guidelines for percutaneous transluminal coronary angioplasty. A report of the ACC/AHA :Task for ceonassessment of dignostic and the rapentic cardiovascular procedures (subcommittee on percutaneous transluminal coronary angioplasty) .Jam Coll call cardial, 1988,12:529
  • 3[3]Chen D, Krasinski K, Sylverster A, et al. Downregulation of cyclindependent kinase 2 activity and cyclin A promoter activity in Vascular smooth muscle cells by P27 (KIPI), an inhibitor of neointimaformation in the rat carotid artery.J clin Invest, 1997,99:2334-2341
  • 4[4]Marx So, Jayaraman T, Go LD, et al. Rapamycin-FKBP inhibits cell cycle regulators of proliferation in vascular smooth muscle cells. Cire Res, 1995,76: 412-417
  • 5[5]Gallo R, Padurean A, Jayaraman T, et al . Inhibition of intimal thickening after balloon angioplasty in porcine coronarly arteries by bargeting regulators of the cell cycle. Circalation, 1999,99:2164-2170
  • 6[6]Feed M, Neil WW Approach to the high-risk-patient. In:Pobin GS, Califf RM, o Neill WW , et al. des. Interventional Cardiovasculra Medicine .Principles and practice. New York: Churchill Living-stone. 1994,293-319
  • 7[7]Pentousis D, Guerin Y , Funck F, et al. Direct stent implantation without predilatation using the Multilink stent .Am JCardiol,1998,82:1437-1440
  • 8[8]Timurkayanak T , Ozdemir M , Cengel A, et al. Direct stentig in angiographically apparent thrombus-containing lesions . J Invasive Cardiol, 2001,13: 742-747
  • 9[9]Hamon M , Richardeau Y, Lecluse E , et al. Direct coronary stenting without balloon predilation in acute coronary syndromes.Am heart J, 1999,138(1 pt 1):55-59

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部