膜类型和操作参数对中药口服液膜分离效果的影响

Effect of Different Membrane and Operation Parameters on Separation Efficiency of Chinese Medicinal Oral Liquid

目的:探讨膜分离金钱通淋口服液时不同膜组件及操作参数对膜分离效果的影响。方法:采用不同截留分子量的膜组件、操作参数的正交设计,以与总黄酮相关的各种指标考察不同膜组件及操作参数对膜分离效果的影响。结果:截留分子量为20 KD的PS膜具有较好的膜分离效果,选择压力0.08 MPa、料液温度40℃、进料流速2.8 L/min的操作参数工作效率更高,但对干膏中总黄酮含量没有显著性影响。结论:膜类型和操作参数对金钱通淋口服液膜分离效果有影响, 新工艺制备的口服液色泽好、澄清度大为改善,且具有良好的药效作用。

Objective:To evaluate the different membranes and its selection of operation parameter on membrane separation efficiency of Jinqian Tonglin Oral Liquid. Methods:Basing on the indexes related to the total flavonoids reserved in liquid, to investigate the effect of the different aperture membrane and operation parameters of orthogonal test on membrane separation efficiency of Jinqian Tonglin Oral Liquid. Results:The PS membrane with 20KD interception molecular weight had better separation efficiency, and the preferred operation parameters were 0. 08 MPa of pressure and 40 C of liquid temperature and 2. 8 L/min of liquid speed, but they had no significant effect on the total flavonoids in dissoluble material. Conclusion: Jinqian Tonglin Oral Liquid prepared by new membrane separation technology has better clearity and colour. It also has good effect.