室温离子液中芳香族亲核取代反应的研究

Aromatic nucleophilic substitution of aromatic halides with thiophenol in ionic liquid.

在1-丁基- 3-甲基咪唑四氟硼酸盐([Bmim]+ BF- 4)离子液中,进行硫酚对活泼芳环的亲核取代反应.实验结果表明离子液对芳香族亲核取代反应有促进作用,使反应加速、产率提高;离子液可多次重复使用,有利于环保.

Aromatic nucleophilic substitution of activated aromatic halides with thiophenol was conducted in NaOH/ionic liquid (++BF -_4) system and unsymmetrical biaromatic sulfides were synthesized. The results indicated that the reaction is accelerated by ionic liquid. It takes the advantage of mild reaction conditions (room temperature and short reaction times) and good yields (80%-95%). But the presence of electron-withdrawing group (NO_2) is necessary to enhance the reaction activity of the substrate and when chlorobenzene was used as substrate the result was not ideal (100 ℃, 24 h, 20% yield). The separation of product from ionic liquid is easy and the ionic liquid can be recovered and re-used easily.