共聚物水凝胶角膜接触镜材料的初期脱水行为

Initial dehydration behavior of copolymer hydrogel for contact lens

以N 乙烯基吡咯烷酮、甲基丙烯酸羟乙酯以及甲基丙烯酸甲酯、甲基丙烯酸乙酯或者甲基丙烯酸丁酯为原料, 制备共聚物水凝胶角膜接触镜材料, 建立了膜状水凝胶材料的脱水模型, 采用重量法和热失重法研究了该材料的初期脱水行为. 结果表明, 水凝胶膜的初期脱水速度与其交联密度的平方成反比; 共聚物水凝胶中N 乙烯基吡咯烷酮的含量越大, 脱水速率越大; 甲基丙烯酸甲酯、甲基丙烯酸乙酯以及甲基丙烯酸丁酯的含量越大, 脱水速率越低, 以甲基丙烯酸乙酯最明显; 在初期脱水阶段, 水凝胶膜的脱水行为可用一级动力学描述.

Hydrogel for contact lens was synthesized by copolymerization of N-vinylpyrrolidone, hydroxyethylmethacrylate, methylmethacrylate or ethylmethacrylate, butylmethacrylate. A dehydration model for hydrogel membrane was established. Initial dehydration behavior of the copolymer hydrogel was studied by the gravimetric and thermal mass loss analysis. The results showed that initial dehydration rate of hydrogel membrane was in inverse proportion with square crosslinking density. N-vinylpyrrolidone in the copolymer increased the dehydration rate, while methylmethacrylate, ethylmethacrylate or butylmethacrylate decreased the dehydration rate. In the initial dehydration stage, the dehydration behavior could be described by means of the first order reaction.