医院真菌感染1225例分析

Analyses of 1225 cases of nosocomial eumycophyta infection

目的探讨医院真菌感染,分析病原菌及病因。方法采集近3年住院患者感染的深部标本进行真菌培养API鉴定,浓度梯度法抽样做白念珠菌的药敏试验及临床资料分析。结果3年共检出1225株真菌,2001—2003年检出率分别为24.2%、27.8%、48.0%。除念珠菌外还分离到隐球菌、马尔尼非青霉菌、组织胞浆菌等。两性霉素B耐药率仅3.3%,而氟康唑的耐药率3年分别为3.4%,8.3%,13.3%。结论真菌感染及其耐药率逐年上升,并与基础疾病及抗生素的使用有关。

Objective To investigate the nosocomial infection of eumycophyta and analyze the pathogen and its cause.Mehtods The samples from the depth infected inpatients in the recent 3 years were gathered to cultivate fungus and API identify. Etest method was sampled to inspect candidacies albicans′ drug susceptibility test.Clinical data were analyzed.at the same time.Results 1 225 cases of fungus infection were detected in the three years.The detection ratio in each year was 24.2%, 27.8%, and 48.0% respectively.Beside of candidacies albicans,cryptococcus, penicillium marneffer and histoplasma capsulatum etc. were examined. The resistance of amphotericin B was the lowest, only 3.3%.The resistance of fluoconazole in each year was 3.4%, 8.3%, and 13.3% respectively three years.Conclusions There was a growing trend of systemic fungus infection and its resistance. The infection ratio was related to the primary pathogen and the use of antibiotics.