摘要
AMP激活的蛋白激酶(AMP-activatedproteinkinase,AMPK)广泛存在于真核细胞中,一旦被激活,即可磷酸化下游靶蛋白,关闭消耗ATP的合成代谢途径,开启产生ATP的分解代谢途径,被称为“细胞能量调节器”。许多新的下游靶蛋白的发现也为AMPK生物学效应的阐明提供了新思路。
The AMP-activated protein kinase is found in all eukaryotic cells. Once activated, the kinase switches on ATP-producing catabolic pathways and switches off ATP-consuming processes,both via direct phosphorylation of downstream targets, and thus is called a 'cellular energy regulator'. A variety of novel downstream target proteins have been discovered recently, which provide new insight into elucidating precise functions of AMP-activated protein kinase.
出处
《生命科学》
CSCD
2005年第2期147-152,共6页
Chinese Bulletin of Life Sciences
基金
国家自然科学基金重大项目(30393131)
关键词
AMPK
能量代谢
AMP
AMP-activated protein kinase
energy metabolism
adenosine monophosphate
