羊膜腔内注射氨基酸治疗胎儿生长受限的研究

Investigation of injecting amino acid into amniotic cavity for intrauterine growth retardation.

目的 探讨羊膜腔内注射氨基酸治疗胎儿生长受限的效果及安全性。方法 采用随机单盲法。将研究对象分成两组,对照组:常规静脉滴注氨基酸+能量,每天一次,共7d ;试验组:羊膜腔内注射小儿氨基酸10 0ml,5～7d一次,每例输注2 - 3次。两组分别于治疗后一月复查腹围、宫高及胎儿双顶径、股骨长,并跟踪至分娩,记录新生儿出生体重。结果 治疗后一月复查,对照组:腹围(86 .4 3±3.0 5 )cm、宫高(2 5 .2 9±2 .4 9)cm、双顶径(7.84±0 .87)cm、股骨长(6 .11±0 .80 )、新生儿出生体重(2 6 14 .2 9±131.93) g ;试验组:腹围(88.5 7±4 .5 3)cm、宫高(2 8.34±3.4 7)cm、双顶径(8.11±1.2 2 )cm、股骨长(6 .36±1.0 4 )cm、新生儿出生体重(2 995 .71±315 .87) g ;两组间比较,除腹围P >0 .0 5 ,差异无显著性,宫高及胎儿双顶径、股骨长及新生儿出生体重均为P <0 .0 1,差异有显著性。结论 羊膜腔内注射氨基酸治疗胎儿生长受限是一种有效、安全的新方法,在临床上值得推广应用。

Objective: To study the effect and reliability of injecting amino acid into amniotic cavity for intrauterine growth retardation. Methods: The investigated patients were divided into two groups by random single blind procedure. The control group accepted amino acid and energy by intravenous cannula infusion per day and the course was 7days. The trial group was injected 100ml amino acid into amniotic cavity once per 5 to 7 days, and every patient was injected 2 to 3 times. After one month post-treatment, the two groups were re-examinated abdomen circumference, level of fundus, fetal biparietal diameter, femur length and tracked to delivery. The birth weight of neonate was recorded. Results: In the control group the abdomen circumference was(86.43±3.05)cm, the level of fundus was (25.29±2.49)cm, the fetal biparietal diameter was (7.84±0.87)ml, the biparietal diameter was (6.11±0.80)ml, the birth weight of neonate was (2614.29±131.93)g. In the trial group the data was(88.57±4.53)cm,(28.34±3.47)cm,(8.11±1.22)cm,(6.36±1.04)cm and(2995.71±315.87)g respectively. There were significant differences in the level of fundus, fetal biparietal diameter, biparietal diameter and birth weight of neonate ( P <0.01) except abdomen circumference ( P >0.05) between the two groups. Conclusions: It's an effective and safe method to inject amino acid into amniotic cavity for intrauterine growth retardation, and is worth to extend in clinical.