小儿单纯性肥胖症胰腺内分泌功能研究

Study on function of pancreatic endocrine in simple obesity in children.

目的 探讨单纯性肥胖(SO)患儿胰腺内分泌功能。方法 采用放射免疫分析法测定SO患儿空腹和摄入液体实验餐6 0min时外周血胰岛素、胰高血糖素和生长抑素(SS)水平。结果 与对照组比较,SO患儿空腹时血中胰岛素、胰高血糖素明显升高(P <0 .0 1) ,而SS水平无明显差异(P >0 .0 5 ) ,其餐后血中胰岛素、胰高血糖素也明显升高(P <0 .0 1) ,而SS水平则明显降低(P <0 .0 1) ;空腹与餐后比较,SO患儿餐后血中胰岛素水平明显升高(P <0 .0 1) ,而胰高血糖素及SS水平无明显变化(P >0 .0 5 )而对照组患儿则血中胰岛素和SS水平升高(P <0 .0 1) ,而胰高血糖素水平无明显变化(P >0 .0 5 )。结论 SO患儿存在明显胰腺内分泌功能紊乱,应引起高度重视。

Objective: In order to reveal the function of pancreatic endocrine in simple obesity in children. Methods: The blood levels of insulin, glucagon and somatostatin before and on 60 minutes after ingestion of test meal were measured by radioimmunassay in 40 children with OB and 30 age-sex matched healthy children as controls. Results: The preprandial levels of insulin and glucagon were higher ( P <0.01), however, the preprandial level of somatostatin was no significant difference ( P >0.05) in OB group than those of control group. The postprandial levels of insulin and glucagon were higher too ( P <0.01), however, the level of somatostatin was lower in OB group than those of control group ( P <0.01). In comparison with the preprandial levels, the postprandial level of insulin was higher ( P <0.01), however, the postprandial levels of glucagon and somatostatin were no significant difference ( P >0.05) in OB group, but in control group, the postprandial levels of insulin and somatostatin were higher ( P <0.01) and glucagon was no significant difference ( P >0.05). Conclusion: The function of pancreatic endocrines is disorder in children with OB.