肝能滴丸对小鼠试验性肝损伤的保护作用研究

Protective Effect of Ganneng Dripping Pills on Experimental Hepatic Injury in Mice

目的 观察肝能滴丸对小鼠试验性肝损伤的保护作用,评价保肝降酶作用。方法 采用化学毒物四氯化碳(CCl4)致小鼠肝脏损伤,测定其生化指标并观察病理组织学改变。结果 肝能滴丸0 .2 34、0 .117g·kg-1均能显著降低CCl4肝损伤所致的小鼠血清谷丙转氨酶(ALT)和谷草转氨酶(AST)升高(P <0 .0 1)。结论 结果表明,肝能滴丸对小鼠试验性肝损伤具有明显的保护作用。

Aim To study the protective effects of Ganneng drip pi ng pills on experimental hepatic injury in mice, and evaluate its effect on redu ced enzyme.Methods Using the model of hepatic injury induced b y hepatoxicity CCl 4,biochemical indexes were determined and the histopathologi cal changes were observed.Results Ganneng dripping pills 0.234 ,0.117g·kg -1 could significantly inhibited the rising of serum ALT and AS T induced by CCl 4 respectively.(P<0.01).Conclution Ganne ng dripping pills had significantly protective effect on experimental hepatic in jury in mice.