60例急性冠脉综合征患者血CRP、FIB及HCY水平临床观察

To observe the levels of C-reactive protein, fibrinogen and homocysteine in blood of 60 patients with acute coronary syndrome

目的:观察对比急性冠脉综合征与非急性冠脉综合征冠心病患者血清C-反应蛋白、纤维蛋白原及血浆同型半胱氨酸水平,从生化角度判断冠状动脉粥样硬化斑块的稳定性。方法:60例急性冠脉综合征患者,44例非急性冠脉综合征冠心病患者为研究对象,检测其外周血C-反应蛋白、纤维蛋白原及同型半胱氨酸水平并作比较。结果:急性冠脉综合征组血清C-反应蛋白、纤维蛋白原(分别为41.74±5.76mg/L,604.53±264.73mg/dl)显著高于非急性冠脉综合征组(分别为4.88±2.49mg/L,353.33±105.68mg/dl),P<0.05。急性冠脉综合征组与非急性冠脉综合征组血浆同型半胱氨酸水平无差别(分别为22.39±16.5μmol/L,17.52±8.31μmol/L)。结论:检测血清C-反应蛋白和纤维蛋白原水平对临床识别冠状动脉粥样硬化斑块的稳定性、鉴别急性冠脉综合征与非急性冠脉综合征冠心病有一定价值。

Objective To measure and compare the levels of C-reactive protein, fibrinogen and homocysteine in blood of patients with acute coronary syndrome (ACS) and non-ACS and to determine the stability of the areriosclerotic mass. Methods 60 ACS patients and 44 non-ACS coronary heart disease (CHD) were chosen to be observed . Serum C-reactive protein, fibrinogen and plasma homocysteine were measured and compared. Results The levels of serum C-reactive protein, fibrinogen of ACS patients (41.74±5.76 mg/L,604.53±264.73 mg/dl) were significantly higher than those of non-ACS patients (4.88±2.49mg/L,353.33±105.68mg/dl).There was no difference between ACS and non-ACS CHD patients in plasma homocysteine (22.39±16.5μmol/L vs 17.52±8.31μmol/L). Conclusion Testing the levels of serum C-reactive protein, fibrinogen contribute to discriminate the stability of the arteriosclerotic and distinguish between ACS and non-ACS CHD in clinic.