BCPT对慢性应激抑郁大鼠行为及体重的影响

Effect of BCPT on behavior and body weight in chronic unpredictable mild stress rats

目的:研究一种拟青霉代谢物提取物(BCPT)对慢性轻度不可预见性应激(CUMS)大鼠行为及体重的影响。方法:采用CUMS法,造成大鼠抑郁模型,定期测量BCPT对该模型大鼠的体重及糖水消耗量,以开野实验的方法测定大鼠水平及垂直活动。结果:与正常组相比,模型组大鼠体重增长缓慢,糖水消耗量明显下降,水平活动和垂直活动均明显下降。与模型组大鼠相比,BCPT组大鼠体重增长略有提高,糖水消耗量明显增加,水平活动和垂直活动均明显增加。结论:本模型为较理想的抑郁模型,BCPT能明显改善抑郁大鼠的行为活动及体重,提示BCPT具有一定的抗抑郁作用。

Objective To probe into the effect of bioactive compounds from paecilomyces tenuipes(BCPT) on behavior and body weight in chronic unpredictable mild stress(CUMS) rats. Methods The depression model rat was produced by CUMS, and the therapy effect of BCPT was observed in CUMS rats. We detected the body weight, sweet water wastage and crossing score, rearing score of rats by open field test. Results The depression model rats′ weight increased and sweet water wastage were lowered, crossing scores and rearing scores were reduced too by open field test compared with normal rats;BCPT could increase body weight, sweet water wastage and the crossing scores and rearing scores of the depression model rats. Conclusion This model was the better resembling depression of disease model,BCPT could obviously improve behavior and body weight of the depressive model rats. The result of this study indicated that BCPT possess certain antidepressant effect.