阿苯达唑和吡喹酮治疗沙鼠泡球蚴病的病理学观察

PATHOLOGICAL STUDIES ON ALVEOLAR HYDATID IN GERBILS TREATED WITH ALBENDAZOLE AND Yquiton

观察阿苯达唑和吡喹酮治疗沙鼠泡球蚴的病理形态学改变、肝脏组织内泡球蚴形态变化和泡球蚴囊周组织反应。为观察疗效，将肝脏泡球蚴分为Ⅰ级：衰退性囊泡、Ⅱ级：静止性囊泡和Ⅲ级：增殖性囊泡。结果显示：阿苯达唑剂量较大组（５０ｍｇ／ｋｇ·ｄ）Ⅰ级囊率最高（Ｐ＜０．０５），其次为吡喹酮两组。早期治疗组比晚期治疗组Ⅰ级囊率为高。泡球蚴囊周淋巴细胞数以阿苯达唑治疗组为高（１０６．９±３４．３—３００．１±５９．５）（Ｐ＜０．０００１）。联合用药组无明显提高疗效作用。

Pathological changes in alveolar hydatids from experimentally infected gerbils were studied after administration of albendazole or yquiton.The animals were divided into several groups including the control one,and drugs of different dosages were given separately to different groups with diverse durations of infection.According to the microscopical observation,the hydatids could be categorized into 3 grades:grade Ⅰ,degenerated cysts;grade Ⅱ, stable cysts (showing no proliferation);gradeⅢ,proliferated cysts.Larger proportion of grade Ⅰ cysts were found in the group treated with albendazole at high dosage(33.3%)and the two groups treated with yquiton(25.0% and 16.3%).The proportion of grade Ⅰ cysts in gerbils with shorter duration (45 d) of infection was larger than those with longer duration(60 d).Lymphocyte infiltration to various extent was present surrounding the alveolar hydatid cysts in all the treated groups.More marked infiltration of lymphocytes was observed in albendazole treated gerbils(106.9±34.3 300.1±59.5)( P <0.001).However,the combined medication of albendazole and yquiton was less efficacious.