蒿甲醚对日本血吸虫糖原、蛋白质、硷性磷酸酶和酸性磷酸酶的影响

EFFECT OF ARTEMETHER ON GLYCOGEN,PROTEIN,ALKALINE PHOSPHATASE AND ACID PHOSPHATASE OF SCHISTOSOMA JAPONICUM

感染日本血吸虫尾蚴３２－３５ｄ的小鼠１次ｉｇ蒿甲醚（Ａｒｔ）３００ｍｇ·ｋｇ－１后２４ｈ，其体内♀、血吸虫的糖原含量较对照组减少约５０％，７２ｈ后则分别减少６４．１％和７７．９％。给药后７２ｈ，♀、虫的蛋白质含量较对照组分别减少６８．１％和４９．３％。给药２４ｈ，♀、虫的硷性磷酸酶（ＡＫＰ）活力的抑制率约为２５％，７２ｈ后，♀虫的ＡＫＰ进一步被抑制，抑制率达６１．６％。酸性磷酸酶（ＡＣＰ）的活力受抑制亦以♀虫较为明显，给药７２ｈ♀、虫抑制率分别为７５．７％和４７．６％。

When mice infected with Schistosoma japonicum for 32-35 d were treated ig withartemethe(rArt)at a single dose of 300 mg.kg-1 for 24 h,the glycogen content of ♀and schistosomes decreased significantly with reduction rates of aboout 50%. 72 h after medica-tion the glycogen reduction rates were 64.1-77.9%.Meantime,the protein content of ♀and worms was also decreased,the reduction rates being 6.1% and 49.3%,respectively.In infected mice treated ig with Art at the same dosage for 24 h,the inhibition rates of alka-line phosphatase(AKP)activity in ♀and worms were 30% and 25%,respectively,72 hlater,the AKP activity of ♀worm was further inhibited to 62.3% as compared with the con- trol.Besides,the inhibitory effect of Art on acid phosphatase(ACP) activity of ♀worm wasalso more apparent than that of worm.72 h after medication,the respective inhibition ratesof ACP activity in ♀and worms were 75.7% and 47.6%,The results indicated that Artmight exert its effect on both carbohydrate and protein metabolism of schistosomes.