表皮钙黏素基因表达与鼻咽癌浸润和转移

E - cadherin expression in invasion and lymphatic metastasis of nasop haryngeal carcinoma

目的探讨表皮钙黏素(E-cadherin,E-CD)基因在鼻咽癌组织中的蛋白表达及其意义。方法用免疫组化技术检测了38例鼻咽癌和43例鼻咽炎症黏膜组织中E-CD蛋白的表达。结果E-CD蛋白在鼻咽炎症黏膜组织中表达率(81.4%),明显高于鼻咽癌中的阳性表达率(55.3%),P<0.05。E-CD蛋白表达与鼻咽癌临床分期相关不明显,P>0.05。与肿瘤的浸润转移呈负相关,即有颈淋巴结转移的鼻咽癌中E-CD表达率(45.8%),明显低于无颈淋巴结转移的鼻咽癌中表达率(71.4%),P<0.05。结论E-CD蛋白表达程度与鼻咽癌浸润、转移有关,通过E-CD蛋白的检测可了解鼻咽癌生物学特性及判断其预后提供有价值的指标。

OBJECTIVE To evaluate the role of E-cadherin(E - CD) expression in invasion and lymphatic metastasis of nasopharyngeal carcinoma. METHODS Tissue sa mples was collected from 38 cases with nasopharyngeal carcinoma and 43 cases wit h inflammation of nasopharyngeal mucosa. The tissue samples were stained with im munohistochemistry method to determine the expression of E - CD. RESULTS The E - CD expression were higher in nasopharyngeal mucosa(81.4 %)than that in nasop haryngeal carcinoma(55.3 %),P < 0.05. Furthermore,a negative correlation was se en between the invasion and lymphatic metastasis of nasopharyngeal carcinoma and the expression of E - CD(P > 0.05). However,no correlation was found between cl inical staging and E - CD. CONCLUSION E - CD activity is related to the inv asion and lymphatic metastasis of the nasopharyngeal carcinoma. E - CD may be a useful marker for determining the biological behavior and prognosis of nasophary ngeal carcinoma.