期刊文献+

苦味受体与甜味、鲜味受体具有不同的进化途径(英文) 被引量:1

Bitter and Sweet/Umami Taste Receptors with Differently Evolutionary Pathways
下载PDF
导出
摘要 通过生物信息学和系统发育学分析,研究了苦味受体和甜味 /鲜味受体的进化途径。结果显示,苦味受体和甜味 /鲜味受体在进化上具有远相关,并且具有不同的进化途径,提示这可能是导致这些受体具有不同功能,传导不同味觉的原因。 In this study,we investigated the evolutionary pathways of bitter,sweet and umami receptors using bioinformatic and phylogenetic analyses.Our results showed that the distantly evolutionary relationship between bitter and sweet/umami receptors.Our results also showed that bitter and sweet/umami receptors have differently evolutionary pathways,suggesting that the different evolutionary pathways may resulte in the differences of these three receptors in function.
出处 《Acta Genetica Sinica》 SCIE CAS CSCD 北大核心 2005年第4期346-353,共8页
基金 国家自然科学基金 中科院创新基金 (编号:KSCX2 1 05 ) 中科院研究生创新项目资助
关键词 进化途径 苦味受体 甜味受体/鲜味受体 基因融合 跨膜区 evolutionary pathways bitter taste receptor sweet/umami taste receptor gene fusion transmembrane domain
  • 相关文献

参考文献33

  • 1Kinnamon S C,Cummings T A.Chemosensory transduction mechanisms in taste.Annu Rev Physiol,1992,54:715~731.
  • 2Lindemann B.Chemoreception: tasting the sweet and the bitter.Curr Biol,1996,6(10) :1234~1237.
  • 3Stewart R E,deSimone J A,Hill D L.New perspectives in a gustatory physiology: transduction,development,and plasticity.Am J Physiol,1997 ,272:1~26.
  • 4Chaudhari N,Landin A M,Roper S D.A metabotropic glutamate receptor variant functions as a taste receptor.Nat Neurosci,2000 ,3 :113~119.
  • 5Lindemann B.A taste for umami.Nat Neurosci,2000,3:99~100.
  • 6Kinnamon S C,Margolskee R F.Mechanisms of taste transduction.Curr Opin Neurobiol,1996,6:506~513.
  • 7Herness M S,Gilbertson T A.Cellular mechanisms of taste transduction.Annu Rev Physiol,1999,61:873~900.
  • 8Gilbertson T A,Damak S,Margolskee R F.The molecular physiology of taste transduction.Curr Opin Neurobiol,2000,10:519~527.
  • 9Hoon M A,Adler E,Lindemeier J,Battey J F,Ryba N J,Zuker C S.Putative mammalian taste receptors: a class of taste~specific GPCRs with distinct topographicselectivity.Cell,1999,96:541~551.
  • 10Adler E,Hoon M A,Mueller K L,Chandrashekar J,Ryba N J,Zuker C S.A novel family of mammalian taste receptors.Cell,2000,100:693~702.

同被引文献23

  • 1于黎,张亚平.食肉目哺乳动物的系统发育学研究概述[J].Zoological Research,2006,27(6):657-665. 被引量:9
  • 2胡锦矗 王酉之.四川资源动物志(第二卷兽类)[M].成都:四川科学技术出版社,1984..
  • 3Wong G T, Gannon K S, Margolskee R F. Transduction of bitter and sweet taste by gustducin [J]. Nature, 1996,381(6585): 796-800.
  • 4Adler E, Hoon M A, Mueller K L, et al. A novel family of mammalian taste receptors[J]. Cell, 2000, 100(6): 693-702.
  • 5Striem B J, Pace U, Zehavi U, et al. Sweet tastants stimulateadenylate eyelase coupled to GTP-binding protein in rat tongue membranes[J]. Biochem J, 1989,260(1):121-126.
  • 6Shi P, Zhang J, Yang H, et al. Adaptive diversification of bitter taste receptor genes in Mammalian evolution [J]. Mol Biol Evol, 2003,20(5):805-814.
  • 7Dong D, Jones G, Zhang S. Dynamic evolution of bitter taste receptor genes in vertebrates[J]. BMC Evol Biol,2009(9):12.
  • 8Ferreira AM, Arajo S S, Sales-Baptista E,et al.ldentification of novel genes for bitter taste receptors in sheep (Ovis aries)[J]. Animal,2012(21):l-8.
  • 9Groenen M A, Archibald A L, Uenishi H,et al. Analyses of pig genomes provide insight into porcine demography and evolution [J]. Nature, 2012,491(7424):393-398.
  • 10Imai H, Suzuki N, Ishimaru Y, et al. Functional diversity of bitter taste receptor TAS2R16 in primates [J]. Biol Lett,2012,8 (4):652-656.

引证文献1

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部