摘要
VHL病(vonHippel-Lindaudisease)是一种遗传性肿瘤综合征,由VHL抑癌基因突变引起。研究表明,VHL蛋白在体内具有多种功能,VHL基因突变形式和部位的差异所造成的VHL蛋白功能增加、减少或缺失可能是导致肿瘤不同表型的重要原因。
VHL disease(von Hippel-Lindau disease) is a kind of hereditary cancer syndrome associated with the mutation of VHL anti-oncogene. It had been implied that VHL could play several roles in vivo, and the addition, reduction or deletion of pVHL protein function may be responsible for different phenotypes of tumor as a result of the difference in mutant forms and sites.
出处
《生物技术通讯》
CAS
2005年第2期194-196,共3页
Letters in Biotechnology
