脑异位慢性血吸虫卵性肉芽肿临床病理分析

Clinicopathological analysis of chronic adventitious schistosomal granuloma in the brain

目的描述慢性脑型血吸虫病虫卵性肉芽肿的病理形态特征。方法手术下切除患者脑部病变活组织,采用石蜡包埋切片,HE染色,光镜下血吸虫卵肉芽肿的病理形态。结果组织切片中可见血吸虫性肉芽肿,虫卵已退变,虫卵外为增生的纤维组织,上皮样细胞和异物巨细胞,形成假结核样结节。结论血吸虫卵肉芽肿是脑型血吸虫病临床表现的病理基础,以退变虫卵为中心的假结核结节是脑型血吸虫病的主要病理学特征。

Objective To explore the pathogenesis, clinical manifestation and pathological characteristics of chronic adventitious schistosomal granuloma in the brain. Methods!!Tissue from patients with chronic ad- ventitious schistosomal granuloma in the brain were pathologically analyzed by paraffin section, HE stain and light microscopy. Result Schistosomal granuloma was seen in tissue slice and eggs had been degenerated. There were hyperplastic fibrous tissue, epithelioid cells and pseudotubercles formed by giant cells. Conclu- sion The pathological change is chronic schistosomal granuloma which cause the clinical manifestations.The diagnosis could be made according to the pathological detection: schistosome ova are detected in the brain focus.