摘要
目的 评价国产硅酮覆膜支架在犬髂动脉内的血液相容性。方法 实验犬 9只。 18条正常髂动脉 ,先行大球囊经皮腔内血管成形术 (PTA)术后置入支架 ,继而置入硅酮覆膜支架 10枚和镍钛合金编织型裸支架 8枚 (对照组 )。术后第 1、4、12周 ,两组分别抽取一定数量支架段血管行DSA观察通畅率和支架内再狭窄程度 ;其后处死动物 ,取出支架段血管 ,作苏木精 伊红染色及组织学检查 ,并对两组支架急性血栓形成情况、支架的内膜覆盖和新生内膜增生程度等作出评价。结果 术后第 1、4、12周DSA所见 :①裸支架组各段时间造影均显示通畅 ,12周时支架段血管狭窄平均为 36 .7% ;②硅酮膜支架组有 2支血管闭塞 (通畅率为 80 % ) ,12周时支架段血管狭窄平均为 72 .3%。
Objective To evaluate the hemocompatibility of domestic silicone-covered stent in the iliac arteries of canine model. Methods Eighteen domestic stents were placed in ililac arteries of 9 adult dogs after larger ballon PTA, which included 10 silicone-covered stents and 8 bare stents for control. DSA was performed at 1,4,12 weeks after stent implantation in the iliac arteries of two groups to observe the outcomes of patency or restenosis. Animals were then euthanized isolating and stainning the stented arteries with hematoxylin and eosin for histological examination. Finally, the acute thrombosis, reendothelialization and the neointimal proliferation of both covered and bare stents were quantified on histological cross-section. Results All bare stents were patent in 12 weeks, but two silicone-covered stents were occluded at 4,12 week respectively (patent rate was 80%). Stented vascular stenosis rate was averaging 72.3% at 12 week in covered stents and 36.7% in bare stents. Conclusions The hemocompatibility of silicone-covered stents is not better than that of bare stents. Silicone appear to be inert in this experimental application.
出处
《介入放射学杂志》
CSCD
2005年第2期175-177,共3页
Journal of Interventional Radiology
基金
上海市"百人计划"资助项目 ( 973 2 0 2 7)