抗氧化剂TA99系列治疗阿尔茨海默病的实验依据(英文)

Experimental basis for antioxidants TA99 series in the treatment of Alzheimer disease

目的:目前基础和临床研究已积累的证据支持氧化应激参与阿尔茨海默病的发生和发展有关的学说,应用抗氧化剂治疗可以改善阿尔茨海默病患者的智力功能和延缓随年龄增加的认知丧失。尽管现有抗氧化剂治疗阿尔茨海默病的基础和临床研究资料仍不一致,但大量现有的实验研究资料是有希望并支持继续此项研究。天然抗氧化剂TA99系列的基础药理实验已强烈提示其为一种很有希望的发展成为治疗阿尔茨海默病的新药。文章就目前研究TA9901作为一种有前景的治疗阿尔茨海默病药物的实验依据以及存在的问题进行综述。资料来源:应用计算机检索Medline数据库1991-01/2004-11期间的相关文章,检索词为“Alzheimerdisease和“antioxidants;Ginkgobilobaextract;TA9901;acetylcholine;senescence-acceleratedmouse等分别组合进行检索,限定文章语言种类为英文。同时计算机检索中国期刊全文数据库\万方数据库1991-01/2004-12期间的相关文章,检索词加速老化小鼠;抗氧化剂;银杏;淀粉样蛋白;阿尔茨海默病;TA9901;乙酰胆碱等,限定文章语言种类为中文。资料选择:对资料进行初审,选取试验包括上述干预组和对照组的文献,然后筛除非随机试验的研究,对剩余的文献开始查找全文。资料提炼:共收集到24篇关于抗氧化剂治疗阿尔茨海默病的基础和?

OBJECTIVE:In recent years, available evidence from basic and clinical research on Alzheimer disease(AD) suggests that oxidation stress is involved in the occurrence and development of AD,and that antioxidant treatment can improve the intelligence of patients with AD and delay age dependant cognitive dysfunction.Although results of basic and clinical research on the therapeutic effects of antioxidants on AD are inconsistent,a large number of available data suggest that these studies are of significance.Basic pharmacological studies on natural antioxidant TA99 series indicate that they are promising novel drugs for AD.Thereby,this study made a review of their experimental basis in the treatment of AD and existing problems. DATA SOURCES:Related articles published between January 1991 and December 2004 were searched by the computer in Medline database with suchas Alzheimer disease,antioxidant,Ginkgo biloba extract,TA9901,acetylcholine,and senescence accelerated mouse in different combinations and with the language limited to English.Meanwhile,related articles were also searched in CDMA\Wanfang data