洛汀新与波依定对原发性高血压患者生活质量的影响

Effects of lotensin and plendil on the quality of life in patients with essential hypertension

目的:观察洛汀新、波依定治疗对原发性高血压患者生活质量的影响,以了解药物对高血压患者生活质量的干预作用。方法:选择2003-09/2004-07上海市浦东新区黄楼医院内科门诊符合纳入标准的原发性高血压患者297例为研究对象。随机将297例患者分为3组:洛汀新组、波依定组、安慰剂组各99例。洛汀新组、波依定组、安慰剂组患者分别接受洛汀新、波依定或安慰剂治疗12周后,采用在健康测量量表(SF-36)研究的基础上,听取了心脏科医师、临床流行病专家、社会科学工作者、统计学家以及结合患者的症状体征加以改进而成的生活质量问卷评估3组患者生活质量,比较3组生活质量的定性和定量变化。同时也比较了3组的血压变化和不良反应。结果:定性生活质量定性观察中,洛汀新组自觉生活质量改善的患者所占百分比明显高于其他两组(P<0.05)。定量观察中,洛汀新组患者治疗后体力健康、精神健康、总体功能和总分3.06±5.18,3.08±5.88,(1.68±4.36,7.82±10.01)均显著高于波依定组(2.65±3.09,1.62±4.05,1.26±4.50,6.00±12.49)和安慰剂组(2.28±4.88,1.38±5.09,0.66±3.65,4.32±10.28)(P<0.05)。洛汀新组和波依定组血压的下降程度明显大于安慰剂治疗组(P<0.05)。结论:洛汀新和波依定都能有效地降低血压,且洛汀新提高高血压患?

AIM:To observe the influence of lotensin and plendil therapy on the quality of life(QOL) in patients with essential hypertension(EH), so as to investigate the interventional effect of drug on the QOL of EH patients. METHODS:Totally 297 EH patients, who were in accordance with the inclusion criteria and treated in the Department of Internal Medicine,Pudong New Area Huanglou Hospital of Shanghai City from September 2003 to July 2004,were randomly divided into lotensin group(n=99),plendil group(n=99) and placebo group(n=99).After the patients in the three groups were treated with lotensin,plendil and placebo respectively for 12 weeks, their QOL was assessed with the QOL questionnaire, which was modified on the basis of health scale short form 36(SF 36),suggestion of cardiological physician,clinical epidemiologist, social scientist and statistician,as well as the symptom physical signs, meanwhile,the changes of blood pressure and adverse effects were also compared among the three groups. RESULTS:The observation of quantitative QOL showed that the percentage of patients had improvement of self conscious QOL in the lotensin group was obviously higher than those in the other two groups(P< 0.05);The scores of physical health, mental health, general function and total score were significantly higher in the lotensin group(3.06± 5.18,3.08± 5.88,1.68± 4.36,7.82± 10.01) than in the plendil group(2.65± 3.09,1.62± 4.05,1.26± 4.50,6.00± 12.49) and placebo group(2.28 ± 4.88,1.38± 5.09,0.66± 3.65,4.32± 10.28)(P< 0.05).Blood pressure decreased more obviously in the lotensin group and plendil group than in the placebo group(P< 0.05).CONCLUSION:Both lotensin and plendil can decrease blood pressure effectively,and lotensin has more obvious effect in improving the QOL of EH patients.