早产儿脑性瘫痪发病危险因素分析

Risk factors of the attack of cerebral palsy in prematures

目的:探讨早产儿脑性瘫痪简称脑瘫的发病危险因素,以便及时诊断()与治疗,从而降低其致残率。方法:选择1998-06/2004-03在湖南省人民医院儿科住院或门诊的67例早产脑瘫患儿,男41例,女26例。选择同期来本院体检的非患脑瘫及神经系统疾病的患儿和健康儿童为对照组,其中男78例,女56例,均系早产儿。对67例脑瘫的早产患儿及134例无脑瘫及其他神经系统疾病早产儿进行研究,所获数据采用非条件Logistic回归分析。结果:多因素分析结果显示小胎龄(OR=0.376,95%CI0.239～0.591)、低出生体质量OR=16.286,95%CI4.032～65.781)、孕期(感染(OR=6.081,95%CI1.062～34.832)、新生儿期严重疾病(OR=14.964,95%CI2.610～85.775),为其发病的主要相关危险因素。结论:早产儿脑瘫发病的相关危险因素主要集中在孕期和围产期,应积极预防和消除各种致病危险因素,从而减低脑瘫发生率。

AIM: To investigate the risk factors of the attack of cerebral palsy (CP) in prematures, so that they can be diagnosed and treated timely, so as to reduce the disabled rate caused by it.METHODS: Sixty seven CP prematures, who were treated or hospitalized in the Department of Pediatrics, Hunan Provincial People's Hospital, and 134 prematures without CP for physical examination or with neurological disease or healthy ones (control group, 78 boys and 26 females), were studied during June 1998 and March 2004. The data were analyzed by non conditional Logistic regression.RESULTS: The results of multiple factor analysis showed that lower gestational age [OR=0.376, 95% confidential interval (CI) 0.239 to 0.591], lower body mass at birth (OR=16.286, 95% CI 4.032 to 65.781), maternal infection during pregnancy (OR=6.081, 95% CI 1.062 to 34.832) and neonatal sever diseases (OR=14.964, 95% CI 2.610 to 85.775) were the main risk factors of CP in prematures.CONCLUSION: Relevant risk factors of CP attack in prematures can be seen primarily in gestational and perinatal periods, various risk factor should be prevented could eliminated actively so as to reduce the incidence rate of CP.