围产期急慢性缺氧新生儿血清尿酸水平与脑肾功能损伤的关系

Correlation of serum uric acid level with brain and renal functional damage of neonates with acute and chronic hypoxia during the perinatal period

目的:应用围产期急、慢性缺氧新生儿血清尿酸水平判断新生儿脑肾功能损伤程度。方法:选择2003-10/2004-11在北京市海淀区妇幼保健院出生的轻度窒息新生儿34例为轻度窒息组,重度窒息新生儿31例为重度窒息组。选择本院同期住院的明确诊断为重度妊娠期高血压综合征(pregnancyinducedhypertensionsyndrome,PIH孕妇所分娩的新生儿30)例为母亲重度PIH组。选择本院同期出生的正常新生儿30例为对照组。分别测定所有患儿及正常新生儿血清尿酸、尿素、肌酐水平,并行脑电图(EEG)检查。结果:轻、重度窒息组、母亲重度PIH组血清尿酸水平明显高于对照组(P<0.01);重度窒息组和母亲重度PIH组新生儿血清尿酸水平犤(349.76±128.41),(330.70±176.14)μmol/L犦明显高于轻度窒息组犤(246.95±109.19)μmol/L犦(P<0.01,0.05)。重度窒息组新生儿异常和可疑EEG所占比率明显高于对照组、母亲重度PIH组(P<0.01),重度窒息组EEG异常率明显高于轻度窒息组(P<0.05)。结论:有围产期急慢性缺氧史的新生儿血清尿酸水平较高,其含量对判断缺氧程度和脑、肾等脏器损伤程度具有重要意义。

AIM:To judge the damage degree of brain and renal functions of neonates with acute and chronic hypoxia during the perinatal period by using their serum level of uric acid(UA). METHODS:Thirty four neonates with mild asphyxia(mild asphyxia group) and 31 cases of severe asphyxia(severe asphyxia group),who were born in the Haidian District Hospital of Women and Children's Health of Beijing City during October 2003 and November 2004,were involved in this study,30 cases whose mother were diagnosed to have pregnancy induced hypertension syndrome(PIH) were selected as the mother with severe PIH group,other 30 normal neonates in this hospital at the same period were taken as the controls(control group).The serum levels of UA,blood urea nitrogen(BUN),creatinine(CRE) were detected and electroencepalograph(EEG) examination was performed in all cases. RESULTS:The serum levels of UA were obviously higher in the mild and severe asphyxia groups and mother with severe PIH group than in the control group(P< 0.01).The serum levels of UA in the severe asphyxia group and mother with severe PIH group[(349.76± 128.41),(330.70 ± 176.14) μ mol/L] were markedly higher than that in the mild asphyxia group[(246.95± 109.19) μ mol/L] (P< 0.01,0.05).The percentages of neonatal disorder and suspected EEG in the severe asphyxia group were remarkably higher than those in the mild asphyxia group and mother with PIH group(P< 0.01),and the EEG abnormal rate was obviously higher in the severe asphyxia group than in the mild asphyxia group(P< 0.05). CONCLUSION:Infants, who has the history of acute and chronic hypoxia during the perinatal period,have a higher serum UA level,which is significant for the judgement of the severity of hypoxia and the damage degrees of brain and renal functions as well as other organs.