摘要
鸡性别决定虽然同哺乳动物一样受遗传控制 ,但其性染色体组成为ZZ ZW ,同哺乳动物相反呈现雌异型 ,并且鸡性腺性别分化同一些低等脊椎动物一样易受性激素影响。目前参照哺乳动物性别决定相关基因已获得了一些鸡同源基因序列 (AMH ,SF1 ,DAX1 ,SOX9)和 3个可能与鸡性别决定有重要关联的候选基因 (DMRT1 ,ASW和FET1 )。对这些基因的表达模式及其在层次调控中的功能比较分析结果显示 ,鸡性别决定的遗传机制同其它脊椎动物相对一致 ,但也有明显的不同。
Birds exhibit genetic sex determination as mammals, but their sex is determined by ZZ∶ZW sex chromosome system, characterized by female heterogamety, contrary to the male heterogamety in mammals, and their gonadal development is sensitive to the estrogen as some lower vertebrates. Several genes (AMH,SF1,DAX1 and SOX9 etc) homogenous with genes critical for mammalian sex determination have been identified in the chicken, and comparative studies of their expression pattern and cascade regulation show that the chicken sex determination mechanism is generally consistent with other vertebrates, but still has distinctions. Subsequently, we present three candidate genes(DMRT1,ASW and FET1)which were detected lately and may be important for chicken sex determination. Chicken is an excellent animal model for research of sex determination and functional genome.
出处
《动物学杂志》
CAS
CSCD
北大核心
2005年第2期106-111,共6页
Chinese Journal of Zoology
基金
中国博士后科学基金资助项目 (No .2 0 0 30 342 6 7)
关键词
鸡
性别决定
候选基因
表达模式
动物模型
Chicken
Sex determination
Candidate gene
Expression pattern
Animal model
