Ki-67和拓扑异构酶Ⅱα在喉鳞状细胞癌中的表达及意义

The expression of Ki-67、topoIIα in laryngeal squamous cell carcinoma

目的:检测喉鳞状细胞癌组织中Ki67、topoⅡα的表达,并分析其表达强度与喉鳞状细胞癌的组织学分级、临床分期及有无淋巴结转移的关系。方法:采用免疫组织化学法检测24例喉鳞状细胞癌及8例(对照组)声带息肉中Ki67、topoⅡα的表达。结果:喉鳞状细胞癌患者Ki67,topoⅡα的阳性率(43.86%,45.74%)明显高于对照组(5.66%,5.98%)(P<0.01),Ki67、topoⅡα的表达强度与癌组织的分化程度相关,topoⅡα/Ki67的比值与是否存在淋巴结转移差异有统计学意义(P<0.05)。结论:Ki67,topoⅡα的表达强度可判断癌组织分化程度,topoⅡα/Ki67可作为喉鳞状细胞癌患者预后的监测指标之一。

objective:To investigate the expression of ki-67 and topoⅡα in laryngeal squamous cell carcinoma, and the relationship between its intensity and the histological grade clinical stage and lymphoma metastasis.Method:The levels of ki-67 and topoⅡα in larynx were measured by immunohistochemical method.Result:The positive rate of ki-67 and topoⅡα in laryngeal squamous cell carcinoma were 43.86% and 45.74%,respectively,and that in the control group were 5.66% and 5.98%,respectively.And significant difference was found between the two groups(P<0.01).The intensity of ki-67 and topoⅡα expression correlated with histological grade. topoⅡα/ ki-67 has a relationship to lymphoma metastasis.Conclusion:The intensity of ki-67 and topoⅡα expression can evaluate the histological grade of carcinoma.topoⅡα/ ki-67 is an indicator of prognosis of Laryngeal Squamous Cell carcinoma.