原发性高血压患者血管内皮功能的超声检测

Vascular Endothelial Function Detected with Ultrasonography in Essential Hypertension

目的应用高频超声评价原发性高血压患者血管内皮功能。方法研究对象60例,分为三组:Ⅰ组原发性高血压患者,Ⅱ组有家族史的高血压前期患者,Ⅲ组正常对照组,分别于反应性充血前后及舌下含服硝酸甘油前后,应用高频超声检侧肱动脉内径变化率,以此评价血管内皮功能。结果原发性高血压组,反应性充血前后血管内径变化率,与正常对照组有显著性差异,而高血压前期组与正常对照组差异无统计学意义。结论高血压患者存在血管内皮功能异常,高血压前期患者血管内皮功能基本正常,因此血管内皮功能障碍是否是高血压形成机制中的一个早期原因值得进一步研究。

Objective To evaluate the endothelial function of essential hypertension patients using ultrasonography. Methods Sixty patients were investigated in this study. All patients were categorized into 3 groups: group Ⅰ , hypertension patients; group Ⅱ, prehypertension patients; group Ⅲ , matched healthy subjects. Every group underwent the ultrasonographic examination of brachial artery diameter in the basic state, reactive hyperaemia and after sublingual glyceryl trinitrate. Results There was significant difference of vessel diameter change in group Ⅰ and group Ⅱ , on the contrary in group II and group Ⅲ there was no difference. Conclusions Abnormal endothelial function exists in hypertension patients, but prehypertension patients always have normal endothelial cell function. So it is still needed to explore the relationship between endothelial dysfunction and early cause of hypertension.