4种脊髓造影剂对蛛网膜影响的实验研究

Experimental study on the influnce of arachnoid from Myodil,Iopamiro,Omnipaque and Isovist

取５０只大白兔分为５组，每组１０只，分别用０．９％氯化钠、Ｍｙｏｄｉｌ（碘苯酯）、Ｉｏｐａｍｉｒｏ（碘异肽醇）、Ｏｍｎｉｐａｑｕｅ（碘苯六醇）、Ｉｓｏｖｉｓｔ（碘帕醇）作脊髓造影。每组于造影后１天、３天、１周、４周、７周各取２只，静脉气栓处死后，取腰、颈段脊髓作光、电镜观察。作者观察到Ｍｙｏｄｉｌ易引起粘连性蛛网膜炎；Ｉｏｐａｍｉｒｏ导致蛛网膜反应性增生远大于Ｏｍｎｉｐａｑｕｅ和Ｉｓｏｖｉｓｔ。

Myelographs were performed in 50 rabbits(divided into 5 groups) with Myodil,Iopamiro,Omnipaque, Isovist and Natrii Chloridi. Animals were killed at various intervals (in 1 day, 3 days, 1 week , 4 weeks and 7 weeks). Lumbar and cervical spinal cord were taken to evaluated histologically by light and electron microscope. The result demonstrated that Myodil is liable to arachnoiditis. The hyperplasia of arachnoid of Iopamiro is much higher than Omnipaque and Isovist.Author's address (The Orthopedic Department of Qingdao Municipal Hospital,Qingdao, Shandong,266011)