脊索瘤的临床病理观察及形态特征的量化研究

Clinical and pathological expression of chordoma and morphological quantitative study of chordoma calls

报告了１５例脊索瘤的临床及病理表现。发生于骶骨１２例，蝶骨、枕骨及腰椎骨各１例。临床明确诊断为脊索瘤者８例，余均诊断为其它良、恶性肿瘤。应用计算机图像分析仪，对１０例脊索瘤的诊断性＂液滴样细胞＂进行了测定，包括细胞及细胞核的面积（Ａ）、周长（ＰＥＲ）、等圆直径（ＣＤ）、最大径（ＭＸ），并计算出平均值和标准差，从而客观地记录了细胞的形态特征，为光镜下诊断脊索瘤提供了量化指标。

Fifteen cases of chordoma were reported,12 in the sacrococcygeal region,2 in the sphenooccipital area,and one in lumbar vertebra.8 cases were diagnosed confirmatively as chordoma.Others were all diagnosed as benign or malignant tumors. Physaliphorous cells were measured by image analysis technique in 10 cases with chordoma,including cells and nuclear area(A),perimeter(PER) ,circle diameter(CD),major axis (MX) and calculated average value,standard difference ,so morphologic features of tumor's cells were recorded objectively.Quantitative norms on light microscopic diagnosis also provided.Author's address Department of Pathology, Third Teaching Hospital,Norman Bethune University of Medical Sciences,Changchun,Jilin ,130021