云南省恶性疟流行概况及其对氯喹的抗性

PREVALENT OUTLINE OF FALCIPARUM MALARIA AND THE RESISTANCE OF P.FALCIPARUM TO CHLOROQUINE IN YUNNAN PROVINCE

云南省是我国恶性疟主要流行区。历史上分布于北纬２５°以南的高、中疟区６５个县（市），海拔１２００ｍ以下的地区。１９８０年全省恶性疟发病数已控制至１０１９例，仅占当年疟疾疫情报告数的３．１６％。由于流动人口的剧增，国外传染源的输入，抗氯喹株恶性疟的扩散，１９９２年恶性疟病例上升至５３７９例，比１９８０年增加４．２８倍，已占全省疟疾疫情报告数的３０．５６％，报告恶性疟的县（市）数已达７４个。几年来通过恶性疟原虫对抗疟药敏感性监测，结果表明氯喹及哌喹抗性程度仍然严重。本文概述了云南省恶性疟流行状况及抗氯喹恶性疟的分布、发展及治疗方案。

Yunnan Province is one of the major falciparum malaria areas in China .In recentyears ,the increase of migrating population has brought about a number of cases of imported falci-parum malaria ,thus widening the distribution of chroloquine-resistant falciparum malaria.5379cases of falciparum malaria were detected in 1992,4.28 times as many as that in 1980,accountingfor 30.99%of the total number of malaria cases in the province and covering 74 counties. Themonitoring over the sensitivity of falciparum parasites to antimalaria drugs showed that falci-parum malaria was still highly resistant to both chloroquine and piperaquine. The status of falci-parum malaria and the distribution of chroloquine-resistant falciparum malaria,its prevalencetrend and therapy were analysed in this paper.